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Protein data
function: oxidoreductaseexperiment: X-RAY DIFFRACTION
resolution: 2.04 Å
origomeric count: 4
axial ligand #1: CYS
chainID: B,resSeq: 449,
Coordination distance[Å]: 2.269
molecule: STEROL 14-ALPHA DEMETHYLASE
EC number: 1.14.13.70
Organism: HOMO SAPIENS
axial ligand #2: VFV
chainID: B,resSeq: 580,
Coordination distance[Å]: 2.054
molecule: N-[(1R)-1-(3,4'-difluorobiphenyl-4-yl)-2-(1H-imidazol-1-yl)ethyl]-4-(5-phenyl-1,3,4-oxadiazol-2-yl)benzamide
List of other hemes in pdb:4uhi
ID of heme | Distortion | Axial ligands on heme | Function & structure | |
---|---|---|---|---|
4uhi-A-540![]() |
sad. -0.17 ruf. -0.29 dom. +0.12 bre. +0.10 |
CYS | chainID: A, resSeq: 449, molecule: STEROL 14-ALPHA DEMETHYLASE |
oxidoreductase oligomeric count: 4 pocket vol.: 440.0 Å3 d(Fe-oop): 0.036 Å |
VFV | chainID: A, resSeq: 580, molecule: N-[(1R)-1-(3,4'-difluorobiphenyl-4-yl)-2-(1H-imidazol-1-yl)ethyl]-4-(5-phenyl-1,3,4-oxadiazol-2-yl)benzamide |
|||
4uhi-C-540![]() |
sad. -0.10 ruf. -0.48 dom. +0.17 bre. +0.09 |
CYS | chainID: C, resSeq: 449, molecule: STEROL 14-ALPHA DEMETHYLASE |
oxidoreductase oligomeric count: 4 pocket vol.: 425.0 Å3 d(Fe-oop): 0.017 Å |
VFV | chainID: C, resSeq: 580, molecule: N-[(1R)-1-(3,4'-difluorobiphenyl-4-yl)-2-(1H-imidazol-1-yl)ethyl]-4-(5-phenyl-1,3,4-oxadiazol-2-yl)benzamide |
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4uhi-D-540![]() |
sad. -0.06 ruf. -0.15 dom. +0.08 bre. +0.08 |
CYS | chainID: D, resSeq: 449, molecule: STEROL 14-ALPHA DEMETHYLASE |
oxidoreductase oligomeric count: 4 pocket vol.: 435.0 Å3 d(Fe-oop): 0.012 Å |
VFV | chainID: D, resSeq: 580, molecule: N-[(1R)-1-(3,4'-difluorobiphenyl-4-yl)-2-(1H-imidazol-1-yl)ethyl]-4-(5-phenyl-1,3,4-oxadiazol-2-yl)benzamide |